Hypocrisie ten top: Nieuwe
kankertherapie St Radboud slaat aan
Een nieuwe kankertherapie die in het
Nijmeegse UMC St Radboud nog selectief wordt toegepast, dentritische celtherapie, is zo
succesvol dat die binnen 5 tot 10 jaar als reguliere behandeling kan worden gegeven voor
diverse typen kanker.
En laat nu juist dit de therapie zijn
waarvoor mensen als Robert Gorter zijn gemangeld door zowel de KWF en de antikwakbrigade
olv Renkens en van Dam.
Ron
Gedifferentieerde cellen kunnen
worden aangezet om weer te gaan delen
Gedifferentieerde cellen die normaal niet
meer kunnen delen, kunnen worden aangezet om weer te gaan delen, blijkt uit onderzoek van
Jerome Korzelius. Dit kan van groot belang zijn voor het begrijpen van kanker en in het
ontwikkelen van therapie voor het herstellen van beschadigd weefsel in volwassenen.
Voor het ontstaan van een volledig
organisme uit slechts een enkele cel is een groot aantal celdelingen nodig. Celdeling
vindt ook nog uitgebreid plaats tijdens het volwassen leven van organismen waaronder de
mens. Dit moet exact gebeuren, want ongecontroleerde celdeling leidt tot het ontstaan van
kanker.
Celdeling wordt bestuurd door twee
verschillende soorten eiwitten: de cyclines en de cycline-gereguleerde kinases of cdk's.
Complexen van cyclines en cdk's regelen elke stap in de deling van de cel, van het
verdubbelen van het erfelijk materiaal tot het verdelen ervan in de twee nieuwe
dochtercellen. Sommige cellen gaan zich na de deling differentieren: ze ontwikkelen zich
verder tot bijvoorbeeld spier- of zenuwcellen. Die differentiatie betekent voor veel
cellen dat ze zich daarna niet meer kunnen delen.
Het proefschrift van Jerome Korzelius
beschrijft hoe cyclines en cdks de celdeling reguleren in de kleine worm C. elegans. In
het bijzonder onderzocht hij hoe spiercellen die zich terug hebben getrokken uit de
delingscyclus weer kunnen worden gestimuleerd om in deling te gaan. Door bepaalde
cycline/cdk combinaties aan te zetten wordt de celdelingcyclus opnieuw geactiveerd in deze
spiercellen. Dit blijkt te gebeuren zonder dat de spiercellen hun spierfunctie verliezen.
Het onderzoek van Korzelius toont tevens
aan dat celdeling van deze cellen minder strikt wordt gecontroleerd dan voorheen werd
gedacht. Voorts kan deze bevinding van groot belang zijn voor ons begrip over het ontstaan
van kanker en het ontwikkelen van methoden om beschadigd weefsel terug te laten groeien.
Professor Peskin has devoted his life to
helping others and finding the truth in a sea of conflicting information. In this
presentation he gives the science and real-life results of proper EFA supplementation and
the connection between Cancer, Heart Disease, and unadulterated parent omega 6 and 3 EFAs,
which he terms Parent Essential Oils or PEOs. For the easy to read pdf of this
presentation and more information on this important subject please visit brianpeskin.com.
Mike
Stress veroorzaakt kanker
Dagelijkse emotionele stress kan tumoren
doen groeien, dat ontdekten Amerikaanse wetenschappers. Onderzoekers ontdekten dat elk
soort trauma, emotioneel of lichamelijk, ervoor kan zorgen dat er zich een 'weg' vormt
tussen kankermutaties.
Wetenschappers uit Israel zien echter wel
relaties tussen trauma's en kanker:
Childhood stress is most damaging.
“There's very good evidence that childhood adversity is associated with a higher
level of inflammation in adulthood and that may persist over time,” she says,
“Kids who been traumatized in a variety of ways--like long term physical or sexual
abuse-- appear to have higher level of inflammation. That could be very a reasonable
mechanism that could contribute to increased risk of cancer here.” [Link]
En in 2008
Women exposed to negative life
events at greater risk of breast cancer
Happiness and optimism may play a role against breast cancer while adverse life events can
increase the risk of developing the disease, according to a study by Professor Ronit
Peled, at Ben-Gurion University of the Negev in Israel. An article on the study titled
"Breast Cancer, Psychological Distress and Life Events among Young Women," was
just published in the British journal BMC Cancer (8:245, August 2008). In the study,
researchers questioned women about their life experiences and evaluated their levels of
happiness, optimism, anxiety, and depression prior to diagnosis. Researchers used this
information to examine the relationship between life events, psychological distress and
breast cancer among young women. A total of 622 women between the ages of 25 and 45 were
interviewed: 255 breast cancer patients and 367 healthy women. "The results showed a
clear link between outlook and risk of breast cancer, with optimists 25 percent less
likely to have developed the disease. Conversely, women who suffered two or more
traumatic events had a 62 percent greater risk," Peled said. "Young
women who have been exposed to a number of negative life events should be considered an
'at-risk' group for breast cancer and should be treated accordingly." The researchers
indicate that women were interviewed after their diagnosis, which may color their recall
of their past emotional state somewhat negatively. However, according to Peled, "We
can carefully say that experiencing more than one severe and/or mild to moderate life
event is a risk factor for breast cancer among young women. On the other hand, a general
feeling of happiness and optimism can play a protective role." "The mechanism in
which the central nervous, hormonal and immune systems interact and how behaviour and
external events modulate these three systems is not fully understood," Peled states.
"The relationship between happiness and health should be examined in future studies
and relevant preventative initiatives should be developed."
RFQMR - Kwakzalverij ?
Ik zag toevallig een item over
"kwakzalverij" met bepaalde apparatuur die gunstig kon zijn bij oa kanker.
Natuurlijk meteen afgebrandt door de gevestigde orde en de bloedhonden van de antikwak. Ik
ben even gaan Googlen en vond nog wel deze studies
--
Efficacy of Rotational Field Quantum
Nuclear Magnetic Resonance (RFQMR) in the treatment of End Stage Terminal Cancer Patients
In conclusion the volunteers were indeed
patients for whom there was no further known treatment available. On top of that, the
majority of the patients had been informed by their treating oncologist that they had a
very limited future life expectancy, often as short as 1 – 3 months. Future life
expectancy in medical terms is hard to predict, especially for most cancer patients.
Still, considering the fact that the patients involved were very ill indeed, an
extraordinary high percentage of the treated patients are still alive. Remarkable
in this aspect are the GBM patients treated. GBM is a very lethal tumor, with normally
death within three to six months after diagnoses. 60% of the GBM patients are still alive
even after two years. We also noted some of the tumors became stable
(non-proliferative). This may be the phase before apoptosis becomes clear. Further basic
research and follow up would be necessary. Almost all patients reported an improvement of
well being after completion of the treatment. Patients reported less pain, more energy,
more appetite, improved strength.
Rotational field quantum magnetic
resonance (RFQMR) in treatment of osteoarthritis of the knee joint
Conclusion
(a) Younger subjects had earlier subjective and objective relief, which was almost
complete at 21 days.
(b) Subjects with lower pain scores (i.e. more pain) showed greater subjective
improvements.
(c) No gender difference to treatment was seen.
(d) No significant difference in status at the end of treatment and at one month was
noted.
(e) Exposure of the knee cartilage to RFQMR is an effective method of treatment and
can be a new line of treatment for osteoarthritis.
Ik vond ook nog een overzicht van mensen
met terminale kanker. Van 4 mensen met longkanker overleefden 3 mensen de 1 jarige studie
terwijl hun levensverwachting max 6 weken was geweest. Totaal waren er van de 38 mensen
met div vormen van kanker na een jaar nog 20 in leven. [Link]
Verder nog een foto mbt artritis knie van
een 57 jarige vroun voor en na
behandeling: [Link]
De club in Leiden bestaat uit oa een
oogarts en een oud commissaris van politie [Link]
Geen idee wat er van waar is maar in een
land waar men vaak niet verder komt dan het vergiftigen van kankerpatiënten mbv chemo
waarmee van de ene patiënt misschien zijn leven wordt verlengd en van de reeds zeer
verzwakte wordt verkort ben ik altijd geïnteresseerd in alternatieve oplossingen die niet
zijn ontwikkeld door een op geld beluste farmaceutische industrie. Heb je ervaring met
deze aanpak mail ons even.
Het apparaat is bedacht door radioloog in
India: [Link]
Mochten de medische maffia de kliniek in
Leiden sluiten dan zul je naar India moeten: [link]. Heksenjacht
wordt wederom door de SP aangewakkerd [link]
Het blokkeren van nucleaire
receptor kan bloedtoevoer naar tumor afsnijden
Een nieuwe methode van het blokkeren van de
genese van bloedvaten die tumoren voeden kan beginnen met de nucleaire receptor COUP-TFII
(kip ovalbumine upstream promotor-transcriptiefactor II), hebben een paar onderzoekers van
Baylor College of Medicine gemeld. Zij hebben de factor meer dan 20 jaar bestudeerd.
In een rapport dat vandaag online is gegaan in de Proceedings of de National
Academy of Sciences, heeft een team welke is geleid door Dr Tsai Ming-Jer en Dr Y. Sophia
Tsai (beiden professoren van de moleculaire en cellulaire biologie op BCM) experimenten
beschreven waarin de groei van nieuwe bloedvaten en tumoren zelf waren onderdrukt toen
COUP-TFII niet aanwezig was.
8-Year Amish Study: Cleaner Living
= Healthier Lives
A new study examining cancer incidence
rates in the Amish underscores the virtues of clean living and how theyre keeping this
tight-knit community healthy. The study, conducted by researchers at Ohio States James
Cancer Hospital and Solove Research Institute, looked at 24 different types of cancer over
an eight-year period and found that overall cancer rates among the Amish are 40 percent
lower than those living outside of an Amish community. The study was recently published in
the journal Cancer Causes and Control.
Cannabisspray tegen kankerpijn
Een mondspray met cannabis kan de pijn van
kankerpatiënten met een derde verminderen, zeggen wetenschappers na een experiment bij
177 patiënten.
There's nothing quite as valuable as seeing
the successes of others who have gone before you. - James Colquhoun, Producer Director
'Food Matters'. 'Rethinking Cancer' tracks the stories of five long-term survivors, whose
recoveries range from 15-37 years, explaining why and how they went a different route with
cancer, and, in one case, Lyme disease. Some were led to seek out alternatives after the
standard course of treatment failed - literally sent home to die by physicians who said
they could do no more for them. Others, after long investigation and soul searching,
bravely chose the non-toxic, biorepair course of action because it seemed a more sensible,
logical approach - that healing could be better fostered by nourishing, repairing and
detoxifying the body, rather than being subjected to toxic substances that would cause
further damage and side effects without addressing the underlying problem.
Lever- en spiereiwitmetabolisme in
kanker cachexia
Voedingsadviezen voor kankerpatienten Een
herkenbaar verschijnsel bij veel kankerpatienten is dat ze extreem afvallen. Cachexie
wordt veroorzaakt door ontstekingsfactoren die door de aanwezigheid van de tumor worden
geproduceerd. Het verlies aan spiermassa in dit proces is bepalend voor de conditie van de
patient. Om dit proces te kunnen remmen met voeding, zou deze enerzijds de spiergroei
moeten bevorderen en anderzijds de afgifte van ontstekingsfactoren tegengaan. Dat
concludeert Stephan Peters in zijn proefschrift waarop hij 17 december promoveert aan de
Universiteit Utrecht. Wisselwerking tussen lever en spierPeters stelt in zijn proefschrift
dat de bewuste ontstekingsfactoren aanzetten tot eiwitproductie in de lever. Dezelfde
ontstekingsfactoren lijken de spierafbraak te stimuleren. Spierafbraak leidt tot
verzwakking van de patient en in extreme gevallen tot overlijden. Hiertoe heeft Peters de
rol van de lever en de spier tijdens cachexie onderzocht. Nieuwe verklaring
spierafbraakSpieren groeien door opname van eiwitten en zogenaamde satellietcellen
(voorlopercellen van de spier). Peters laat zien dat ontstekingsfactoren de opname van de
satellietcellen in de spiervezels lijken lam te leggen. Optimale voedingPeters concludeert
dat een optimale voeding voor de patient moet bestaan uit eiwit, met daarin de juiste
bouwstenen voor eiwitaanmaak in de lever en de spier. Daarnaast moet de voeding ook
componenten bevatten die de ontstekingsfactoren remmen (bijvoorbeeld visolie) zodat de
satellietcellen weer in de spieren opgenomen kunnen.
Interview over fruit en kanker
Rob Hundscheidt
Scientists Hope New Test Will Help
Fight Cancer
UZ Brussel stelt revolutionaire
kankertherapie voor
Het UZ Brussel stelt vandaag als eerste
ziekenhuis ter wereld het Vero-systeem voor hogeprecisieradiotherapie voor.
Volgens Clevers speelt stress geen rol bij
kanker. Volgens Israelische onderzoekers is er wel degelijk een verband tussen
bijvoorbeeld een trauma en verhoogde kans op kanker (link).
Al eerder toonde Israelische onderzoekers aan tussen borstkanker bij vrouwen en trauma's
in de jeugd: They found that a generally positive outlook appeared to reduce the chance of
breast cancer by a quarter. In addition, exposure to one or more of the traumatic
"life events" such as loss of a parent or a spouse increased the risk by more
than 60%.
New research shows that the longer it takes
to develop a cancer clinical trial, the less likely it is that the trial will meet its
goal for accruing patients and the less able it will be to report a statistically
significant result.
Killing Tumor Cells with the Bee
Venom component - Melittin!
When bees sting, they pump poison into
their victims. Now the toxin in bee venom has been harnessed to kill tumor cells by
researchers at Washington University School of Medicine in St. Louis. The researchers
attached the major component of bee venom to nano-sized spheres that they call nanobees.
In mice, nanobees delivered the bee toxin melittin to tumors while protecting other
tissues from the toxin's destructive power. The mice's tumors stopped growing or shrank.
The nanobees' effectiveness against cancer in the mice is reported in advance online
publication Aug. 10 in the Journal of Clinical Investigation. "The nanobees fly in,
land on the surface of cells and deposit their cargo of melittin which rapidly merges with
the target cells," says co-author Samuel Wickline, M.D., who heads the Siteman Center
of Cancer Nanotechnology Excellence at Washington University. "We've shown that the
bee toxin gets taken into the cells where it pokes holes in their internal
structures." Melittin is a small protein, or peptide, that is strongly attracted to
cell membranes, where it can form pores that break up cells and kill them. "Melittin
has been of interest to researchers because in high enough concentration it can destroy
any cell it comes into contact with, making it an effective antibacterial and antifungal
agent and potentially an anticancer agent," says co-author Paul Schlesinger, M.D.,
Ph.D., associate professor of cell biology and physiology. "Cancer cells can adapt
and develop resistance to many anticancer agents that alter gene function or target a
cell's DNA, but it's hard for cells to find a way around the mechanism that melittin uses
to kill."
50% kankersterfte te voorkomen door
gezonde leefstijl
Ongezond leven staat aan de basis van
tenminste 50% van de sterfgevallen door kanker. Bijna tweederde van de Nederlanders is van
mening dat leefstijl een grote rol speelt bij het ontstaan van kanker.
Losjes gebaseerd op Alice in Wonderland
proberen wij u uit te leggen wat de waarheid is rondom, en de achterliggende reden is van
geïmpregneerd hout, groene stroom, mileubeton en de miljarden euro’s aan
milieusubsidie die wij betalen aan onze AVI’s (groene-stroomcentrales). Tevens zult u
gaan begrijpen waarom kanker doodsoorzaak nummer 1 is in Nederland. Als u schrikt is dat
een volkomen normale reactie, als u boos wordt ook. Graag willen wij u wel troosten met de
opmerking dat er een oplossing voorhanden is. U kunt het in onderstaand artikel allemaal
lezen. Wij hopen dat u het wilt kopiëren en verspreiden omdat het misschien wel het
belangrijkste stuk is wat u in jaren hebt gelezen. Over kopierechten doen wij niet
moeilijk: die heeft u bij deze.
Vermeld u er dan wel bij waar het vandaan kwam?
Cancer is projected to be the number one
cause of death worldwide by the year 2010. This frightening disease can affect anyone at
any time in their lives. The terror, confusion and physiological deterioration that Cancer
causes devastates not only those who are afflicted by it, but everyone in their lives as
well. Everyone needs to arm themselves with the right information to help to protect them
against this dreaded disease. Join Gary Null Ph.D. and the world's leading Alternative
Cancer Experts to learn powerful strategies to prevent or reverse Cancer.
Preventing & Reversing Cancer
Naturally Trailer
Cancer is projected to be the number one
cause of death worldwide by the year 2010. This frightening disease can affect anyone at
any time in their lives. The terror, confusion and physiological deterioration that Cancer
causes devastates not only those who are afflicted by it, but everyone in their lives as
well. Everyone needs to arm themselves with the right information to help to protect them
against this dreaded disease. Join Gary Null Ph.D. and the world's leading Alternative
Cancer Experts to learn powerful strategies to prevent or reverse Cancer.
Oxidative Stress, Does This
Increase A Woman's Cancer Risk?
Dr. Thomson shares if life-long athletes
have an increased cancer risk caused by oxidative stress.
The Beautiful Truth Dr Max Gerson
Garrett is a 15-year old boy living in the
Alaskan wilderness with a menagerie of orphaned animals. Growing up close with nature has
given him a deep understanding of nutritional needs required by diet sensitive animals on
the reserve. Unfortunately, the untimely and tragic death of his mother propelled him into
a downward spiral and he risked flunking out of school. This led to his fathers decision
to home-school Garrett. His first assignment was to study a controversial book written by
Dr. Max Gerson. Written over 50 years ago, Dr. Gerson found that diet could, and did, cure
cancer. Controversial at the time (and even today), Garrett took on the challenge of
researching this amazing therapy, which drew the interest of his neighbors in the small
Alaskan community. With the help of Dr. Gersons daughter, Charlotte Gerson, and grandson,
Howard Strauss, they gave him the ammunition needed to go in search for the truth a truth
that would affect not only him, but his entire Alaskan village all of whom wanted to know
if these claims were true. After a number of cancer patients, who were diagnosed as
terminal, shared their stories and their medical records with Garrett, it became
abundantly clear that, contrary to the disinformation campaign spear-headed by the
multi-billion dollar medical and pharmaceutical industry, a cure for virtually all cancers
and chronic diseases does exist and has existed for over 80 years!
Rethinking Cancer
Rethinking Cancer is a educational
documentary film that provides a rare look into the psychological and therapeutic journeys
of five men and women who used biological therapies to overcome serious illness. Their
stories represent successes that mainstream medicine and the public ought to know about.
Four of the featured subjects had been diagnosed with cancer; two of these patients were
considered terminal cases. The fifth patient had a severe case of Lyme disease. All five
have outlived their diseases, between 15 and nearly 40 years, thus far. Rethinking Cancer
is a educational documentary film that provides a rare look into the psychological and
therapeutic journeys of five men and women who used biological therapies to overcome
serious illness. Their stories represent successes that mainstream medicine and the public
ought to know about.
Boek - Crazy Sexy - passievol
(over)leven met kanker
Wanneer Kris Carr op haar 31ste te horen
krijgt dat ze een zeldzame vorm van kanker heeft, besluit ze niet bij de pakken neer te
gaan zitten, maar de ziekte een
"make-over" te geven: ze maakt een film over haar leven met kanker en schrijft
een boek met tips hoe om te gaan met deze ziekte. Ze wint er diverse prijzen mee.In
haar nieuwe boek, Crazy Sexy, herdefinieert Kris wat het is om een overlever te zijn.
Doordat ze haar leven weer in eigen hand heeft genomen, merkt ze dat haar ziekte nu
gestabiliseerd is “ tegen alle medische verwachtingen in. Ze beschrijft met typische
humor en wijsheid haar spirituele overlevingstocht, geeft advies en oefeningen en biedt
ruimte om zelf te schrijven en te reflecteren. Het boek toont aan dat het mogelijk is een
gek, sexy en waarachtig leven te leiden met kanker, en het leert bovendien dat ware heling
is gelegen in oprecht leven.Kris Carr is actrice, fotografe en documentairemaakster. Aan
haar opmerkelijke verhaal is aandacht besteed in de Oprah Winfrey-show, en ze werd
enthousiast onthaald door o.a. Sheryl Crow, Marianne Williamson, dr. Mehmet Oz, Donna
Karan, Lance Armstrong en anderen. Kris Carr geeft lezingen en workshops over gezond eten
en leven en heeft een veelgelezen blog op www.crazysexylife.com.
Hoera!!!!!!! Nederlandstalig. Geschreven
door een kankeroverleefster en super positief/baanbrekend persoon. De rauwe veganistische
eetstijl.
Petra
Met een enkele prik kankervrij
Van cavia en hond tot tijger. Hoogleraar en
chirurg Jolle Kirpensteijn krijgt de meest uiteenlopende kankerpatiënten op zijn
snijtafel. Bij moeilijke gevallen past hij sinds kort een revolutionaire methode toe, die
wellicht op afzienbare termijn ook bij mensen toepasbaar is.
One way a Virus or Bacterium can
cause Metastatic Cancer
Professor Trevor Marshall of Murdoch
University explains how a Virus or Bacterium can knock out a key body defense against
Breast cancers - the gene MTSS1.
Presentation of Stefaan Van Gool's
project : Tumor Vaccination
Kanker en koorts
Kanker kan soms vanzelf afnemen of zelfs
helemaal verdwijnen. Dit onverklaarbare verschijnsel kan cruciale aanwijzingen opleveren
voor een beter inzicht in deze ziekte en hoe we die het best kunnen behandelen.
Kanker kan soms vanzelf afnemen of zelfs
helemaal verdwijnen. Dit onverklaarbare verschijnsel kan cruciale aanwijzingen opleveren
voor een beter inzicht in deze ziekte en hoe we die het best kunnen behandelen. De meesten
van ons accepteren de gangbare medische opvatting dat ongeveer een op de drie mensen op
zeker moment in hun leven kanker krijgt. Ook wordt de ziekte algemeen gezien als een
progressieve en agressieve aandoening, die gewoonlijk vier stadia doorloopt en
uiteindelijk fataal zal zijn wanneer ze niet met succes wordt behandeld. Niettemin
komt er steeds meer bewijsmateriaal dat kanker ook gewoon vanzelf kan verdwijnen of, zoals
oncologen het noemen, spontane regressie kan vertonen.
Praten we hier niet gewoon over de aanmaak
van vitamine D ? Iets waar het KWF ons juist bang voor maakt?
Ron
Jeff Rense interviews Ty Bollinger
- Cancer Truth
Radio talk show icon Jeff Rense interviews
Ty Bollinger, author of Cancer-Step Outside the Box (http://www.cancertruth.net) about
alternative cancer treatments, the swine flu, the medical mafia, cell phones and brain
cancer, and more. In this interview, Jeff Rense calls Ty's book "the Bible of Cancer
Treatments." Will oncologists submit to chemotherapy if they are diagnosed? Well, in
1986, McGill Cancer Center in Montreal, one of the largest and most esteemed cancer
treatment centers in the world, surveyed 64 oncologists to see how they would personally
respond to a diagnosis of cancer. The results will blow your mind. Are you sitting down?
Of the 64 oncologists surveyed, 58 said that... ALL chemotherapy programs were
unacceptable to them and their family members due to the fact that the drugs dont work and
are toxic to ones system! That's right, 91% of oncologists will not take chemo!! Listen in
as Jeff and Ty have one of the most mind blowing radio interviews in history. Visit the
website and BUY THE BOOK THAT JUST MIGHT SAVE YOUR LIFE ONE DAY: http://www.cancertruth.net
Polymeren verbeteren combinaties
van antikankertherapieën
Twan Lammers beschrijft in zijn
proefschrift hoe HPMA-copolymeren de effectiviteit van therapieen die chirurgie,
radiotherapie en chemotherapie combineren, kunnen verbeteren. Het onderzoek van Lammers
laat zien dat HPMA-copolymeren lang circuleren effectief en selectief in tumoren
opeenhopen. Verder heeft hij de polymeren gecombineerd met radiotherapie. Hieruit bleek
dat enerzijds de radiotherapie de opeenhoping van de polymeren in de tumor verbeterde, en
anderzijds de polymeren zowel de effectiviteit als de toxiciteit van radiochemotherapie
verbeterden. Daarbij toonde de promovendus aan dat HPMA-copolymeren in staat zijn meerdere
chemotherapeutica tegelijkertijd naar tumoren te transporteren. Daarmee zijn ze geschikt
om de effectiviteit van combinaties van chemotherapie te verbeteren. Tenslotte beschrijft
Lammers in zijn proefschrift dat de HPMA-copolymeren kunnen worden gebruikt om de
combinatie van chemotherapie en chirurgie te verbeteren.
Gerichte vernietiging van
tumorcellen door het afweersysteem
Allogene stamceltransplantatie en
donorlymfocyten-infusie worden toegepast bij de behandeling van verschillende soorten
kanker, met name leukemie. Bij deze behandeling kan een positieve afweerreactie optreden
waarbij tumorcellen van de patiënt aangevallen worden door zogenaamde T-cellen afkomstig
van het getransplanteerde afweersysteem van de donor. Dit komt door herkenning van
ontvanger-specifieke eiwitten op de tumorcellen. Helaas gaat deze positieve afweerreactie
vaak gepaard met een schadelijke reactie tegen gezonde weefsels. Om selectief de gunstige
afweerreactie te stimuleren wordt onderzoek gedaan naar eiwitten die aanwezig zijn op
tumorcellen, maar niet op cellen van gezonde weefsels. Ingrid Overes onderzocht een nieuw
ontvanger-specifiek eiwit. Dit eiwit blijkt selectief voor te komen op cellen van
verschillende soorten bloedkanker en solide tumoren. Daarnaast kunnen T-cellen specifiek
gericht tegen dit eiwit tumorcellen herkennen en vernietigen. Dit betekent dat dit eiwit
geschikt is om verder te bestuderen als aangrijpingspunt voor gerichte immunotherapie bij
verschillende soorten kanker na stamceltransplantatie.
Voeding tegen kanker
Hallo Ron,
Het wereldkankeronderzoeksfonds prijst de
volgende 20 voedingsmiddelen aan om jezelf te beschermen tegen kanker
Met post 3, 5, 13, 15, 16, 18, en 20 kan ik
onmogelijk akkoord gaan om de tussen haakjes aangehaalde redenen.
1.rode en oranje pepers,
2.kool,
3.knoflook, (niet geschikt als bron van methionine)
4.uien,
5.waterkers, (kan beter vervangen worden door veldsla of Romeinse sla)
6.broccoli,
7.spinazie,
8.zoete aardappelen,
9.tomaten,
10.spruiten,
11.wortelen,
12.kiwi,
13.mango’s, (cassisbessen zijn beter voor dagelijks gebruik)
14.aardbeien,
15.Braziliaanse noten, (bevatten teveel fytinezuur)
16.volgranenbrood, (bevat teveel fytinezuur)
17.zalm,
18.zonnebloemenzaad, (niet de juiste verhouding omega-3 / omega-6; 1/136; moet zijn 1/3)
19.sinaasappelen,
20.olijfolie. (niet de juiste verhouding omega-3 / omega-6; 1/17; moet zijn 1/3)
Korte uitleg:
3. Knoflook: Om gezond te worden en het te
blijven moet onze dagelijkse voeding een beter evenwicht in de aanvoer van essentiële
aminozuren nastreven.
5. Waterkers: Veldsla bevat ~0,25 alfalinoleenzuur en Romeinse sla ook, je kan er meer van
eten dan van waterkers.
13. Mango’s als dagelijkse voeding gebruiken is veel moeilijker dan cassisbessen.
15. Brazilnuts bevatten 2 à 6,3 % fytinezuur dat de opname van mineralen belet. Waarom
staan hier geen okkernoten.
16. Volgranenbrood bevat 1 à 3% fytinezuur en dat leidt dikwijls tot mineralen
deficiëntie. Als volgranenbrood met zuurdesem gebakken wordt is de fytinezuurhoeveelheid
aanvaardbaar. Tarwekiembrood is ook geschikt.
18. Zonnebloemzaad heeft een slechte verhouding omega-3 / omega-6 vetzuren wat kan leiden
tot teveel onstekingsreacties. Pompoenpitten of hennepzaden hebben een betere verhouding.
20. Olijfolie: Idem als 18, er is heden een tekort aan alfalinoleenzuur en met de 20
vermelde voedingsmiddelen wordt dat niet opgelost. Vlaszaad en dito olie kan dat wel
oplossen.
Ik kan de wereld niet verbeteren maar ik
blijf zoeken naar de meest gezonde voedingsmiddelen.
A San Diego researcher has developed a way
to tag cancer cells for early detection in the blood stream. Professor Michael Sailor
hopes to dramatically change how cancer is treated. He is on a quest to create
nanoparticles that travel the bloodstream, latch onto cancers in their earliest stages and
destroy them. Sailor's project is staging the war on cancer at the nano-level. The armed
forces he is amassing are a thousand times smaller than the diameter of a human hair.
Klaartje Kok deed onderzoek naar een bepaald gen dat van belang is bij onder meer allergie
en immuniteit. Ze ontdekte het DNA-element dat de werking van het gen reguleert. Ook
vergroot haar onderzoek het inzicht in de rol van dit gen bij
ontstekingen en het ontstaan van kanker: ze laat zien dat een gebrek hieraan bescherming
biedt tegen kanker. Dat is hoopgevend nieuws, want momenteel worden in de kliniek
zogeheten p110 remmers getest, medicijnen die de expressie van het gen tegengaan.
Tumoren creeren hun eigen bloedvatenstelsel
zodat ze kunnen groeien. Deze bloedvaten zijn essentieel maar anders en minder perfect dan
gewone bloedvaten. Door specifiek cellen van deze bloedvaten aan te vallen kan de
doorbloeding in de tumor stagneren waardoor tumorcellen massaal dood gaan. Marcel Fens
beschrijft in zijn proefschrift verschillende manieren om de bloedvaten van tumoren aan te
vallen. Het maximale effect op de tumoren dat Fens met methoden bereikte is tijdelijke
remming van de groei. Doordat een (klein) deel van de tumorcellen overleeft, ziet de tumor
toch kans zich te herstellen. In de toekomst zullen combinatietherapieen wellicht een
toegevoegde waarde hebben in de verbetering van deze anti-tumorstrategie.
Cancer - Step Outside the Box
Discover the TRUTH about cancer that your
doctor probably doesn't know and the drug companies hope you never find out. If
you’re concerned about the “C” word, then Cancer - Step Outside the Box is
the book you’ve been waiting for. It reveals the most potent and well-proven
strategies for preventing and treating cancer... without barbaric procedures like surgery,
chemotherapy, or radiation.
Überteuerte Medikamente, Rabatte
für Krankhäuser oder finanzielle Unterstützung für behandelnde Mediziner - wie die
Pharma-Branche und Ärzte abkassieren.
Chlorella can Replace a Closet Full
of Expensive Supplements
If you could only have one supplement,
which one would you choose? For its high nutrient content and potent defense against
disease and the ravages of aging, many people have put chlorella at the top of their list.
Now there are even more reasons to cheer for chlorella. Scientists are documenting its
potent cancer fighting abilities including its ability to repair damage to DNA and
influence gene expression.
St. Jude defines eye cancer gene's
role in retinal development
A genetic discovery led by scientists at St. Jude Children's Research Hospital helps
answer a long-standing mystery about the eyes of vertebrates, and may translate into a
deeper understanding of how genes coordinate the complex process of eye formation and how
a rare pediatric eye cancer progresses.
Jefferson scientists uncover role
of cancer stem cell marker - controlling gene expression
Scientists at Jefferson's Kimmel Cancer Center in Philadelphia have made an extraordinary
advance in the understanding of the function of a gene previously shown to be part of an
11-gene "signature" that can predict which tumors will be aggressive and likely
to spread. The gene, USP22, encodes an enzyme that appears to be crucial for controlling
large scale changes in gene expression, one of the hallmarks of cancer cells.
Viruses use many tricks to gain control over their host cells and to reprogram them to
their own advantage. Dr. Arnd Kieser and his colleagues of the Department of Gene Vectors
of the Helmholtz Zentrum Munich, Germany, were able to show in a recent publication in
PLoS Biology by which mechanism Epstein-Barr virus exploits a signal protein of its host
cell, which normally mediates programmed cell death, in order to convert the cell into a
cancer cell.
Consuming extra virgin olive oil
helps to combat degenerative diseases such as cancer
Researchers from the University of Granada have for the first time analyzed the
antioxidant properties of olive oil, a product rich in polyphenols. The Environmental,
Biochemical and Nutritional Analytical-Control Research Group had already carried out the
polyphenolic characterization of food products, such as honey and beer.
A protein that shields tumor cells from cell death and exerts resistance to chemotherapy
has an Achilles heel, a vulnerability that can be exploited to target and kill the very
tumor cells it usually protects, researchers from the University of Illinois at Chicago
show in a new study published in the Dec. 9 issue of Cancer Cell. Akt is a signaling
protein, called a kinase, that is hyperactive in the majority of human cancers. "Akt
is perhaps the most frequently activated oncoprotein (cancer-promoting protein) in human
cancer," says Nissim Hay, professor of biochemistry and molecular genetics at the UIC
College of Medicine. Pharmaceutical companies have been trying to find ways to inhibit Akt
to improve cancer therapy, he said, but most candidate drugs have acted too broadly and
proved toxic. "One of Akt's major functions in tumor cells is promoting cell
survival," Hay said. "Tumor cells with hyperactive Akt are not only resistant to
the external stresses that can induce cell death but also to chemotherapy."
A study by the MUHC and McGill
University opens a new door to understanding cancer
An in-depth understanding of the mechanisms that trigger cancer cell growth is vital to
the development of more targeted treatments for the disease. An article published in the
August 3 issue of Molecular Cell provides a key to these mechanisms that may prove crucial
in the future. The paper is co-authored by Dr Morag Park, Director of the MUHC Molecular
Oncology Group, and Dr Kalle Gehring, Head of the Nuclear Magnetic Resonnance Laboratory
of the McGill University Biochemistry Department.
“To understand cancer, it is necessary to first understand how the molecules
interact,” explains Dr. Park, who is also a Professor of oncology and biochemistry at
McGill University. “In that study we have clarified the structure of some of the
proteins involved and their connections, which allows us to understand the consequences of
these interactions.” This is, in fact, a feat that merits close attention, because it
means that researchers can now “see” elements smaller than a millionth of a
millimetre!
In a cell’s interior, the function of the ubiquitin molecule is to “clean
house.” It attaches itself to proteins that must disappear and triggers their
degradation; in doing so, it allows a number of mechanisms to be minutely controlled. This
new study reveals that ubiquitin also promotes interactions between proteins known as
Cb-b. In a healthy patient, Cb-b is activated when a growth factor attaches itself to the
surface of a cell, its role being to mitigate the cell proliferation and growth mechanisms
induced by the factor. However, in some cancer patients this mitigation mechanism does not
appear to function, partly because the ubiquitin does not attach itself correctly to the
cell surface and to Cb-b. As a result, the effects of the growth factor become much more
pronounced, which results in an unrestrained proliferation of cells – that can become
a cancer.
ESF EURYI award winner aims to stop
cancer cells reading their own DNA
A promising new line in anticancer therapy by blocking the molecular motors involved in
copying genetic information during cell division is being pursued by young Dutch
researcher Dr. Nynke Dekker in one of this year's EURYI award winning projects sponsored
by the European Science Foundation and the European Heads of Research Councils.
Scientific Proof that Your
Childhood Traumas are a MAJOR Factor in Your All Your Illnesses
The Adverse Childhood Experiences (ACE) Study is an ongoing research project which is
perhaps the largest scientific research study of its kind. Its purpose it to analyze the
relationship between multiple categories of childhood trauma and health and behavioral
outcomes later in life.
New tool could unpick complex
cancer causes & help sociologists mine Facebook
Researchers at the University of Warwick’s Department of Statistics and Centre for
Complexity Science have devised a new research tool that could help unpick the complex
cell interactions that lead to cancer and also allow social scientists to mine social
networking sites such as Facebook for useful insights. An approach called "graphical
models" can be used by researchers to gain an understanding of a range of systems
with multiple interacting factors. These models use mathematical objects called graphs to
describe and depict the probability of relationships between each of the components. When
used to study molecular biology researchers may be interested in saying something about
which molecules influence one another; in the social sciences researchers would use them
to understand the relationships between various economic and demographic factors. However
gaining such information from a graphical model can be a very challenging exercise,
because of the vast range of possible graphs needed for even a relatively small number of
variables. For instance the relatively small network studied by the University of Warwick
led team for this research paper had just 14 proteins which were implicated in the
development of a form of cancer, but those 14 proteins had a vast number of combinations
of possible mutual interactions.
UC Davis team refines cancer
treatments to reduce potential nerve damage
While radiation treatments deliver precise doses of high-energy X-rays to stop cancer
cells from spreading or to shrink tumors, oncologists have become increasingly concerned
about inadvertent exposures during head and neck cancer treatments to nerves responsible
for upper body mobility.
FSU chemists using light-activated
molecules to kill cancer cells
A key challenge facing doctors as they treat patients suffering from cancer or other
diseases resulting from genetic mutations is that the drugs at their disposal often don't
discriminate between healthy cells and dangerous ones -- think of the brute-force approach
of chemotherapy, for instance. To address this challenge, Florida State University
researchers are investigating techniques for using certain molecules that, when exposed to
light, will kill only the harmful cells.
High-intensity ultrasound may
launch attack on cancer, wherever it lurks
an intense form of ultrasound that shakes a tumor until its cells start to leak can
trigger an "alarm" that enlists immune defenses against the cancerous invasion,
according to a study led by researchers at Duke University's Pratt School of Engineering.
Exciting discovery could 'stop
cancer from killing people'
Metastasis is the ability of cancer cells to spread from a primary site, to form tumours
at distant sites. It is a complex process in which cell motility and invasion play a
fundamental role. Essential to our understanding of how metastasis develops is
identification of the molecules, and characterisation of the mechanisms that regulate cell
motility. Hitherto, these mechanisms have been poorly understood. Now, a team of
researchers lead by Professor Marco Falasca at Barts and The London School of Medicine and
Dentistry has shown not only that the enzyme phospholipase C?1 (PLC?1) plays a crucial
role in metastasis formation, but that down regulation of PLC?1 expression is able to
revert metastasis progression. The team investigated the role of PLC?1 in cell invasion
and metastasis using different approaches to modulate its expression in highly invasive
cancer cell lines. Their results showed that PLC?1 is required for breast cancer cell
invasion and activation of the protein Rac1. They revealed a functional link between PLC?1
and Rac1 that provides insight into processes regulating cell invasion.
An enzyme that mutates antibodies
also targets a cancer-causing oncogene
The human immune system runs a risky business. It mutates its own DNA to diversify
defenses against foreign invaders it has never before encountered. Unfortunately, these
mutations sometimes miss the mark, and the result can be lethal cancer. Now Rockefeller
University scientists have found that the same enzyme that enables an effective immune
response is also responsible for the DNA breaks that cause lymphomas.
Researcher invents lethal 'lint
brush' to capture and kill cancer cells in the bloodstream
In a new tactic in the fight against cancer, Cornell researcher Michael King has developed
what he calls a lethal "lint brush" for the blood -- a tiny, implantable device
that captures and kills cancer cells in the bloodstream before they spread through the
body. The strategy, which takes advantage of the body's natural mechanism for fighting
infection, could lead to new treatments for a variety of cancers, said King, who is an
associate professor of biomedical engineering. In research conducted at the University of
Rochester and to be published in an upcoming issue of the journal Biotechnology and
Bioengineering, King showed that two naturally occurring proteins can work together to
attract and kill as many as 30 percent of tumor cells in the bloodstream -- without
harming healthy cells.
Researchers from Virginia Commonwealth University have identified a new anti-tumor gene
called SARI that can interact with and suppress a key protein that is overexpressed in 90
percent of human cancers. The discovery could one day lead to an effective gene therapy
for cancer.
Study of placenta unexpectedly
leads to cancer gene
University of Rochester Medical Center scientists discovered a gene mutation that impairs
the placenta and also is influential in cancer development, according to a study published
online December 16, 2008, in the journal PLoS (Public Library of Science) Biology. The
investigation is the first to link the key placental gene, SENP2, to the well-known p53
protein, which is defective in 50 percent of all cancers. Until now, the SENP2 gene's role
in early embryo development was not known. As a result of making the connection between
SENP2 and the potent cancer stimuli, it will be possible to gain more insight into the
complex genetic network involved in cancer, and to develop new therapies, said lead author
Wei Hsu, Ph.D., associate professor of Biomedical Genetics and Oncology, of the James P.
Wilmot Cancer Center. Hsu and former graduate student Shang-Yi Chiu, currently a
postdoctoral fellow at Howard Hughes Medical Institute, Dana-Farber Cancer Institute at
Harvard University, have been investigating how cellular signaling triggered by gene
mutations affect embryo development in mice. The goal is to better understand the genetic
causes and possible treatments for a number of diseases. "What we discovered was an
unexpected interaction between an old player, p53, and a new player, SENP2," said
Hsu, who also has an appointment in the URMC Center for Oral Biology.
"When you grill meat some of the fat does drip down on to the charcoal and when fat
meets that really high temperature it develops a carcinogen and the smoke carries the
carcinogen back up to the meat which can be dangerous for our bodies," explains
Schaub.
Groundbreaking, inexpensive,
pocket-sized ultrasound device can help treat cancer, relieve arthritis
A prototype of a therapeutic ultrasound device, developed by a Cornell graduate student,
fits in the palm of a hand, is battery-powered and packs enough punch to stabilize a
gunshot wound or deliver drugs to brain cancer patients. It is wired to a ceramic probe,
called a transducer, and it creates sound waves so strong they instantly cause water to
bubble, spray and turn into steam.
Not long ago, I asked a respected cancer researcher if he could send me raw data from a
trial he had recently published. He refused. Sharing data would make the study team
members “uncomfortable,” he said, as I might use this to “cast doubt”
on their results.
Tumors use enzyme to recruit
regulatory T-cells and suppress immune response
One way tumors fly under the radar of the immune system is by using IDO, an enzyme used by
fetuses to help avoid rejection, to recruit powerful regulatory T cells that turn down the
immune response, researchers say.
Modified gene targets cancer cells
a thousand times more often than healthy cells
Researchers at the University of Rochester have designed a gene that produces a thousand
times more protein in cancer cells than in healthy cells. The findings may help address
the prime challenge in anticancer therapy, improving treatments' ability to specifically
and effectively target cancer cells. Using this new approach, scientists should be able to
insert "self-destruct" codes into the modified gene, forcing cancer cells to
kill themselves while healthy cells remain largely unaffected.
New oral angiogenesis inhibitor
offers potential nontoxic therapy for a wide range of cancers
The first oral, broad-spectrum angiogenesis inhibitor, specially formulated through
nanotechnology, shows promising anticancer results in mice, report researchers from
Children's Hospital Boston. Because it is nontoxic and can be taken orally, the drug,
called Lodamin, may be useful as a preventive therapy or as a chronic maintenance therapy
for a variety of cancers, preventing tumors from forming or recurring by blocking the
growth of blood vessels to feed them.
Researchers have discovered two enzymes that, when combined, could be involved in the
earliest stages of cancer. Manipulating these enzymes genetically might lead to targeted
therapies aimed at slowing or preventing the onset of tumors. "We could conceivably
reactivate a completely normal gene in a tumor cell – a gene that could prevent the
growth of a tumor if reactivated," says David Jones, Ph.D., professor of oncological
sciences at the University of Utah and senior director of early translational research at
the university's Huntsman Cancer Institute (HCI). "We believe this could be one of
the earliest processes to go wrong in cancer," he adds. "By manipulating these
enzymes, we could possibly prevent or slow the onset of tumors." The enzymes appear
to control an "on–and-off switch" for critical genes that could trigger
cancer or numerous other diseases and birth defects. The research is published in the
December 26 issue of Cell. Using zebrafish that share similar genetics to humans, the HCI
scientists identified a previously unknown enzyme process that controls the levels of DNA
methylation on genes. "Methylation is a cellular process that is required for healthy
cell growth and development, but it can go awry in cancer and diseased cells," says
Brad Cairns, Ph.D., HCI investigator and professor of oncological sciences at the
University of Utah. "You can think of DNA methylation as an on-and-off switch.
Methylation silences or 'shuts off' genes that need to be turned off or are not
functioning as they should, whereas the reverse process called demethylation 'turns on'
healthy genes and genes needed at critical times in development," he says.
Modified Gene Targets Cancer Cells
a Thousand Times More Often Than Healthy Cells
Researchers at the University of Rochester have designed a gene that produces a thousand
times more protein in cancer cells than in healthy cells. The findings may help address
the prime challenge in anti-cancer therapy - improving treatments' ability to specifically
and effectively target cancer cells. Using this new approach, scientists should be able to
insert "self-destruct" codes into the modified gene, forcing cancer cells to
kill themselves while healthy cells remain largely unaffected. Though trials will be
necessary to determine if the difference is enough to destroy tumors without harming
healthy tissue, the initial findings, published in today's early edition of Proceedings of
the National Academy of Sciences, are promising, say the authors.
Blood clots are increasingly common in cancer patients, but University of Rochester
Medical Center researchers have created a novel risk model that can predict, with 98
percent certainty, which patients will not get a blood clot.
“If I contracted cancer, I would never go to a standard cancer treatment centre.
Cancer victims who live far from such centres have a chance.” Professor Charles
Mathe, French cancer specialist Doctors are too busy to dig into the statistics of cancer
treatments, they assume that what they are taught at school or what is demonstrated in the
pages of briefing journals is the best treatment. They cannot afford to suspect that these
treatments are only the best for the pharmaceutical companies that influence their
'institutions of higher learning'.” Paul Winter, The Cancell Home Page, dedicated to
exposing the fraud behind pharmaceutical company controlled medical research institutions
and their deliberate withholding of information from the general public on safe cancer
treatments.
Dormant cancer cells rely on
cellular self-cannibalization to survive
A single tumor-suppressing gene is a key to understanding, and perhaps killing, dormant
ovarian cancer cells that persist after initial treatment only to reawaken years later,
researchers at The University of Texas M. D. Anderson Cancer Center report in the December
Journal of Clinical Investigation. The team found that expression of a gene called ARHI
acts as a switch for autophagy, or self-cannibalization, in ovarian cancer cells. Often a
mechanism for cancer cell death, in this case "self-eating" acts as a survival
mechanism for dormant cancer cells. "Prolonged autophagy is lethal to cancer cells,
but a little autophagy can help dormant cancer cells survive, possibly by avoiding
starvation," said senior author Robert Bast, M.D., vice president for translational
research at M. D. Anderson. "Dormant cells are a major problem in ovarian cancer,
breast cancer and other malignancies," Bast said. "We often see ovarian cancer
removed, leaving no remaining sign of disease. After two or three years, the cancer grows
back. If any remaining cancer cells had continued to grow normally, the disease should
have returned in weeks or months.
UCLA researchers clarify function
of glucose transport molecule
UCLA scientists have solved the structure of a class of proteins known as sodium glucose
co-transporters, which pump glucose into cells. The solution of the SGLT structure will
accelerate development of new drugs designed to treat patients with diabetes and cancer.
The journal Science publishes the findings.
“New blood” can revitalize a company or a sports team. Recent research by Tel
Aviv University finds that young blood does a body good as well, especially when it comes
to fighting cancer. The TAU researchers, led by Prof. Shamgar Ben-Eliyahu from the
Department of Psychology’s Neuroimmunology Research Unit, discovered that a
transfusion of “young” blood — blood which has been stored for less than 9
days — increased the odds of survival in animals challenged with two types of cancer.
This finding, reported in the journal Anesthesiology, may solve an age-old mystery as to
why some blood transfusions during cancer-related surgeries may lead to an increased
recurrence of cancer and others do not.
Boston researchers have developed a test that can identify minute amounts of tumor cells
floating in the blood of cancer patients, a discovery that could lead to better treatments
with fewer side effects.
Soft Coral Reef Offers Hope in the
Fight Against Cancer
The search for novel, bioactive compounds with anti-cancer activity is proceeding full-
speed ahead in Rutgers' new Center for Marine Biotechnology. The center's two
co-directors, Drs. Paul Falkowski and Richard Lutz, announced the exciting discovery of
several new compounds isolated from a shallow-water coral that induced cell death
(apoptosis) in cancer lines maintained in the laboratory of Dr. Eileen White of Rutgers'
Center for Advanced Biotechnology and Medicine.
Protein's essential role in
repairing damaged cells revealed
University of Michigan researchers have discovered that a key protein in cells plays a
critical role in not one, but two processes affecting the development of cancer."Most
proteins involved in responding to DNA damage that can cause cancer either help detect the
damage and warn the rest of the cell, or help repair the damage," says David O.
Ferguson, M.D., Ph.D., the study's lead author. Ferguson is an assistant professor of
pathology at the U-M Medical School and a member of U-M's Comprehensive Cancer Center.
Chemopreventive agents in black
raspberries identified
A study published in Cancer Prevention Research, a journal of the American Association for
Cancer Research, identifies components of black raspberries with chemopreventive
potential. Researchers at the Ohio State Comprehensive Cancer Center found that
anthocyanins, a class of flavonoids in black raspberries, inhibited growth and stimulated
apoptosis in the esophagus of rats treated with an esophageal carcinogen. "Our data
provide strong evidence that anthocyanins are important for cancer prevention," said
the study's lead author, Gary D. Stoner, Ph.D., a professor in the department of internal
medicine at Ohio State University. Stoner and his team of researchers fed rats an
anthocyanin-rich extract of black raspberries and found that the extract was nearly as
effective in preventing esophageal cancer in rats as whole black raspberries containing
the same concentration of anthocyanins. This study demonstrates the importance of
anthocyanins as preventive agents in black raspberries and validated similar in vitro
findings. It is among the first to look at the correlation between anthocyanins and cancer
prevention in vivo. Stoner and his colleagues have conducted clinical trials using whole
berry powder, which has yielded some promising results, but required patients to take up
to 60 grams of powder a day. "Now that we know the anthocyanins in berries are almost
as active as whole berries themselves, we hope to be able to prevent cancer in humans
using a standardized mixture of anthocyanins," said Stoner. "The goal is to
potentially replace whole berry powder with its active components and then figure out
better ways to deliver these components to tissues, to increase their uptake and
effectiveness. Ultimately, we hope to test the anthocyanins for effectiveness in multiple
organ sites in humans," said Stoner.
Scientists can now differentiate
between healthy cells and cancer cells
One of the current handicaps of cancer treatments is the difficulty of aiming these
treatments at destroying malignant cells without killing healthy cells in the process. But
a new study by McMaster University researchers has provided insight into how scientists
might develop therapies and drugs that more carefully target cancer, while sparing normal
healthy cells Mick Bhatia, scientific director of the McMaster Stem Cell and Cancer
Research Institute in the Michael G. DeGroote School of Medicine, and his team of
investigators have demonstrated – for the first time – the difference between
normal stem cells and cancer stem cells in humans. The discovery, published in the
prestigious journal Nature Biotechnology today, could eventually help with the further
customization and targeting of cancer treatments for the individual patient. It will
immediately provide a model to discover drugs using robotic screening for available
molecules that may have untapped potential to eradicate cancer.
Sheets of highly organized epithelial cells line all the cavities and free surfaces of the
body, forming barriers that control the movement of liquids and cells in the body organs.
Now, the researchers at the University of Helsinki, Finland, have found that the organized
structure of normal breast epithelial cells may also serve as a barrier against cancer.
Control switches found for immune
cells that fight cancer, viral infection
Medical science may be a significant step closer to climbing into the driver's seat of an
important class of immune cells, researchers at Washington University School of Medicine
in St. Louis report in Nature Immunology.
A team of scientists from the Dublin-Oxford NIBRT Glycobiology Laboratory have developed a
system which can pinpoint potential "biomarkers" of early forms of cancer, by
looking at structures of specific sugar molecules which are attached either to proteins of
cancerous cells or to proteins involved in the host response. The availability of such
cancer biomarkers could also allow disease progression and response to therapy to be
monitored more easily and accurately than is currently possible.
U-M researchers discover new genes
that fuse in cancer
Using new technologies that make it easier to sequence the human genome, researchers at
the University of Michigan Comprehensive Cancer Center have identified a series of genes
that become fused when their chromosomes trade places with each other. These recurrent
gene fusions are thought to be the driving mechanism that causes certain cancers to
develop. The gene fusions discovered could potentially serve as a marker one day for
diagnosing cancer or as a target for future drug development. In the new study, published
in Nature, the researchers identified several gene fusions in prostate cancer cells. Some
of the fusions were seen in multiple cell lines studied, while other gene fusions appeared
only once. The fusions were found only in cancer cells, and not in normal cells. "We
defined a new class of mutations in prostate cancer. The recurrent fusions are thought to
be the driving mechanism of cancer. But we found other fusions as well, some of which were
unique to individual patients. Our next step is to understand if these play a role in
driving disease," says Arul Chinnaiyan, M.D., Ph.D., director of the Michigan Center
for Translational Pathology and S.P. Hicks Endowed Professor of Pathology at the U-M
Medical School. Chinnaiyan's team was the first to identify rearrangements in chromosomes
and fused genes in prostate cancer. Gene fusions had previously been known to play a role
in blood cell cancers such as leukemia and lymphoma, and in Ewing's sarcoma.In the current
study, the researchers showed that newer techniques could identify these gene fusions more
quickly and easily.
Nearly a century later, new
findings support Warburg theory of cancer
German scientist Otto H. Warburg's theory on the origin of cancer earned him the Nobel
Prize in 1931, but the biochemical basis for his theory remained elusive. His theory that
cancer starts from irreversible injury to cellular respiration eventually fell out of
favor amid research pointing to genomic mutations as the cause of uncontrolled cell
growth.Seventy-eight years after Warburg received science's highest honor, researchers
from Boston College and Washington University School of Medicine report new evidence in
support of the original Warburg Theory of Cancer. A descendant of German aristocrats,
World War I cavalry officer and pioneering biochemist, Warburg first proposed in 1924 that
the prime cause of cancer was injury to a cell caused by impairment to a cell's power
plant – or energy metabolism – found in its mitochondria. In contrast to healthy
cells, which generate energy by the oxidative breakdown of a simple acid within the
mitochondria, tumors and cancer cells generate energy through the non-oxidative breakdown
of glucose, a process called glycolysis. Indeed, glycolysis is the biochemical hallmark of
most, if not all, types of cancers. Because of this difference between healthy cells and
cancer cells, Warburg argued, cancer should be interpreted as a type of mitochondrial
disease.
A new red fluorescent protein—derived from a brilliant red sea anemone purchased in a
Moscow pet shop—can reveal body tissues more vividly than other fluorescent proteins
in use today. The Russian researchers who developed the new protein said it can render
cancers and other target tissues easily visible in living animals, making them glow like
Christmas bulbs.
Technology which will make it possible to semi-automate the process for detecting
cancerous tumours more precisely is being developed by academics at the University of
Hertfordshire. Dr Soodamani Ramalingam and her team at the University are developing 3-D
object recognition and image processing so that it will be possible to get a more accurate
picture of human tumours so that cancers can be identified and treated accordingly.
Cancer Is Not A Disease - It's A
Survival Mechanism
Did you know that 95% of all cancers appear and disappear on their own, and that treating
them actually prevents them from being cured? The prominent cancer researcher and
professor at the University of California, Dr. Hardin Jones, admitted: "Patients are
as well, or better off, untreated....My studies have proven conclusively that cancer
patients who refuse chemotherapy and radiation actually live up to four times longer than
treated cases, including untreated breast cancer cases." In Cancer Is Not A Disease,
bestselling author and internationally acclaimed health expert, Andreas Moritz, proves the
point that cancer is not a separate illness, but the result of specific, identifiable
causes. Removing these causes sets the precondition for the body, mind and emotions to
become healed, meaning, whole again. Medical intervention, on the other hand, attempts to
remove the symptoms of disease with almost complete disregard to their cause(s). This is
not only unscientific and unethical, but also life endangering. Each year over 900,000
people in the U.S. lose their lives needlessly to medical treatment. Even one single dose
of chemotherapy or radiation can be fatal for both the tumor and the patient. The success
record of modern cancer therapy is dismal, even less than the weakest placebo response. On
average, remission occurs in about 7% of all cancers, not because of, but despite these
aggressive treatments.
UGA researchers discover mechanism
that explains how cancer enzyme winds up on ends of chromosomes
Researchers at the University of Georgia's Franklin College of Arts and Sciences have
shown a mechanism that explains how two essential components of human telomerase --
normally active only in early prenatal development but turned back on during cancer growth
-- are "recruited" from distinct sites in the cell to the telomere, an area at
the end of a chromosome that normally protects it from destruction.
Cancer researchers at the
University of Pennsylvania discover what makes lymphomas tick
University of Pennsylvania researchers and their colleagues at the Wistar Institute and
University of Oxford have discovered the molecular process by which the PAX5 protein,
necessary for lymphocyte development, promotes the growth of common lymphomas, thereby
unveiling a potential new target in the fight against cancer.
Report on patients' access to
cancer drugs 'uses flawed methods to reached flawed conclusions'
A leading epidemiologist has attacked Swedish research that looked at inequalities in
patients' access to cancer drugs across Europe and the world. In a commentary published in
the September issue of the cancer journal, Annals of Oncology, Professor Michel Coleman
says the Karolinska report is so badly flawed that no safe conclusions can be drawn from
it about cancer survival, and he highlights the role played by a major drug company in
funding the research.
Experimental anti-cancer drug made
from corn lillies kills brain tumor stem cells
A drug that shuts down a critical cell-signaling pathway in the most common and aggressive
type of adult brain cancer successfully kills cancer stem cells thought to fuel tumor
growth and help cancers evade drug and radiation therapy, a Johns Hopkins study shows.
Scientists have provided new details about how cancer cells spread by surrounding
themselves with platelets -- the blood cells needed for blood clotting. These results
could help design new drugs that prevent cancer cells from metastasizing, or spreading
throughout the body.
Scripps Florida scientists find
novel use for old compound in cancer treatment
The compound, ?-difluoromethylornithine or DFMO, targets the activity of a specific enzyme
and, even in very limited doses, is effective in protecting against the malignancy in
animal models. "The drug, which was developed as a cancer therapy and later shelved
because of toxicity concerns, has been around since the 1970s," said John Cleveland,
Ph.D., chair of the Scripps Florida Department of Cancer Biology whose laboratory
conducted the study. "But over the past five years, it has undergone a rebirth as a
chemoprevention agent, first showing efficacy in animal models of human cancer and more
recently in human prostate and colon cancer. Our study shows that it likely works in a
large cast of tumors, even those having poor prognosis, like high-risk
neuroblastoma." Neuroblastoma is a childhood malignancy of the sympathetic nervous
system (part of the nervous system that serves to accelerate the heart rate, constrict
blood vessels, and raise blood pressure) that accounts for nearly eight percent of all
childhood cancers and 15 percent of pediatric cancer-related deaths. Its solid tumors
arise from developing nerve cells, most commonly in the adrenal gland, but also in the
abdomen, neck, and chest. Neuroblastoma usually occurs in infants and young children,
appearing twice as frequently during the first year of life than in the second.
Tragically, children with stage IV, high-risk neuroblastoma have a less than a 40 percent
chance of long-term survival.
Melanoma drug revs immune cells but
cancer cells ignore it
a new study shows that an important drug used in the treatment of malignant melanoma has
little effect on the melanoma cells themselves. Instead, it activates immune-system cells
to fight the disease. The drug, called interferon alpha, is used to clean up microscopic
tumor cells that may remain in the body following surgery for the disease. It is the only
drug approved for this purpose.
Brown Researchers Work Out
Structure of TIGAR, a Possible Cancer Flag
Two Brown University researchers have determined the three-dimensional structure of an
enzyme whose presence in the body could help doctors detect cancer earlier or develop more
targeted treatments.Hua Li and Gerwald Jogl detail their progress with the enzyme known as
TIGAR in a paper to be published Jan. 16, 2009, in The Journal of Biological
Chemistry.“It will help us to understand where else we should be looking for good
[anti-cancer] targets,” said Jogl, assistant professor of biology in the Department
of Molecular Biology, Cell Biology and Biochemistry at Brown. Jogl is the study’s
principal investigator and corresponding author. Li is a fifth-year Ph.D. student based in
Jogl’s lab and is the lead author.
Key protein that may cause cancer
cell death identified
Researchers at A*STAR's Institute of Molecular and Cell Biology (IMCB) have become the
first to discover and characterize a human protein called Bax-beta (Bax?), which can
potentially cause the death of cancer cells and lead to new approaches in cancer
treatment. The finding is published in the 16 Jan. report of Molecular Cell. Detection of
Bax? has eluded scientists until now. Said Dr Victor Yu, principal investigator of the
IMCB research team, "Our research findings reveal that Bax? protein levels are
normally kept at essentially undetectable levels in healthy cells by the protein
degradation machine in cells known as proteasomes. Proteasomes are "protein-digesting
machines" that regulate cellular levels of various proteins including that of the
lethal Bax?, by breaking them into smaller components within the cell. "Thus, the
proteasomes are there to keep the lethal Bax? in check," he added. "This is
exciting — if the proteasome-mediated degradation of Bax? could be inhibited
specifically in cancer cells, it could cause the harmful cancer cells to go through
apoptosis". In apoptosis, unwanted, damaged and infected cells are eliminated. Until
the discovery of Bax? by Dr. Yu's team, only one single protein called Bax-alpha (Bax?)
had been extensively studied in cells. Earlier evidence had suggested that more than one
protein was encoded by the Bax gene.
Dartmouth researchers identify
potential cancer target
Dartmouth Medical School researchers have found two proteins that work in concert to
ensure proper chromosome segregation during cell division. Their study is in the January
2009 issue of the journal Nature Cell Biology. This finding is relevant for treating solid
cancerous tumors that lose the ability to accurately segregate their chromosomes. Tumors
that shuffle chromosomes, a process called chromosomal instability, are known to have a
poor prognosis. "We show that the function of two proteins, called Kif2b and MCAK, is
to correct improper attachments during cell division to prevent the mis-segregation of
chromosomes" said Duane Compton, the senior author on the paper and a professor of
biochemistry at Dartmouth Medical School. "The two proteins share the workload as
Kif2b acts early in cell division and MCAK acts later. This cooperation underlines the
importance of proper chromosome segregation for the healthy life of all cells."
Compton is also director of the Cancer Mechanisms Research Program at Norris Cotton Cancer
Center at Dartmouth-Hitchcock Medical Center. Compton explained this finding follows a
study his team published in the February 2008 issue of The Journal of Cell Biology that
showed that the main cause of chromosomal instability is that chromosomes make improper
attachments to the spindle apparatus during cell division. "These improper
attachments occur normally during cell division in all cells, but in the tumor cells, the
improper attachments fail to get corrected and cells attempt to divide with persistent
improper attachments," said Compton.
Scientists at Georgia Tech have developed a potential new treatment against cancer that
attaches magnetic nanoparticles to cancer cells, allowing them to be captured and carried
out of the body. The treatment, which has been tested in the laboratory and will now be
looked at in survival studies, is detailed online in the Journal of the American Chemical
Society.
Researchers Discover Link between
Organ Transplantation and Increased Cancer Risk
Researchers have determined a novel mechanism through which organ transplantation often
leads to cancer, and their findings suggest that targeted therapies may reduce or prevent
that risk. In the July 15, 2008, issue of Cancer Research, researchers at Harvard Medical
School found in animal and laboratory experiments that the anti-rejection,
immunosuppressive drug cyclosporine ramps up expression of vascular endothelial growth
factor (VEGF), which signals the growth of new blood vessels that can feed tumors. They
also found that simultaneously administering an anti-VEGF therapy with cyclosporine in
mice repressed this tumor growth. Several inhibitors of VEGF are already in use in human
cancer therapy.
Weizmann Institute scientists' new
technique gets to the root of cancer
In two complementary studies, Weizmann Institute scientists have developed a new method
for reconstructing a cell's 'family tree,' and have applied this technique to trace the
history of the development of cancer. So far, the scientists have been able to calculate
the age of the tumor and characterize its growth pattern. The scientists believe cell
lineage studies of cancer can eventually lead us to the root of cancer.
Fruits and Vegetables in Cancer
Prevention and Treatment
Relatively recently, researchers have become keenly interested in exploring which food
compounds are beneficial in treating and preventing serious diseases such as cancer and
osteoporosis. Omer Kucuk, MD, is one of those researchers. Kucuk, a professor of
hematology and medical oncology at Emory Winship Cancer Institute, studies specific food
compounds and their effect on cancer prevention and treatment. Evidence indicates that
some food compounds, such as soy isoflavones and curcumin, can increase the effectiveness
of chemotherapy and radiation therapy. To listen to Kucuk’s own words about which
food compounds affect cancer prevention and treatment, access Emory's new Sound Science
podcast. Kucuk conducted the first clinical trials to show the benefits of soy and
lycopene supplements in prostate cancer treatment. “In our preclinical studies we
have observed that taking soy isoflavones during chemotherapy and radiation for advanced
prostate cancer can improve the efficacy of the treatments," says Kucuk. “The
compounds sensitize the cancer cells to chemotherapy and radiation while at the same time
they protect the normal tissues from side effects.” Most nutritional compounds used
for therapy or disease prevention can be taken as part of a routine diet and have little
if any side effects, Kucuk says. “People can get enough lycopene by eating tomato
paste and tomato sauce, which is very rich in lycopene. So, if people ate a couple of
ounces of tomato paste a day as part of a regular diet, they would eat enough to get all
the benefits,” he says. Kucuk and his colleagues are currently exploring how soy
isoflavones make chemotherapy and radiation more effective. “These are pleiotropic
agents. That means they affect multiple pathways in cancer cells as well as other
cells,” Kucuk says. “This is actually good, because a lot of the drugs that are
developed target one pathway, and they’re usually very toxic. But because nontoxic
nutritional compounds work with multiple pathways they have mild side effects making them
very attractive for treatment.”
Important advance in the treatment
of cancer and viral infections
Dr. André Veillette, a researcher at the Institut de recherches cliniques de Montréal
(IRCM), and his team led by postdoctoral fellow Dr. Mario-Ernesto Cruz-Munoz, will publish
in the upcoming issue of the prestigious journal Nature Immunology of Nature Publishing
Group. This discovery could have a significant impact on the treatment of cancers and
infectious diseases. Current treatments frequently achieve only limited results with these
types of diseases, which affect hundreds of thousands of Canadians. Dr. Veillette's team
identified one of the basic mechanisms controlling NK ("natural killer") cell
activity. Produced by the immune system, NK cells are responsible for recognizing and
killing cancer cells and cells infected by viruses, such as viruses causing hepatitis and
herpes. NK cell deficiency is associated with a higher incidence of cancers and serious
infections. "Our breakthrough, comments Dr. Veillette, demonstrates that a molecule
known as CRACC, which is present at the surface of NK cells, increases their killer
function." Using mice, the researchers have shown that CRACC greatly improves the
animals' ability to eliminate cancer cells such as melanoma (a skin cancer) and lymphoma
(a blood cancer). Mice lacking the CRACC gene, generated in Dr. Veillette's laboratory,
were found to be more susceptible to cancer persistence. Conversely, stimulation of CRACC
function was found to improve cancer cell elimination. Thus, stimulating CRACC could boost
NK cell activity, helping to fight cancers. In addition, it could improve the ability to
fight infections, which are also handled by NK cells. Increasing the activity of CRACC by
gene therapy or drugs could become an option in the future to stimulate the killer
function of NK cells, and to improve their capacity to destroy cancer and virus-infected
cells. These approaches could be used in combination with chemotherapy and radiotherapy to
increase the effectiveness of anti-cancer treatments. Teams of scientists around the world
have been trying for many years without success to develop methods to increase NK cell
activity. In this light, the discovery of Dr. Veillette's team opens new avenues for the
treatment of cancers and viral infections.
Scientists from the Helmholtz Centre for Infection Research (HZI) have discovered a class
of natural substances that are produced by soil bacteria and prevent somatic cells from
dividing. After years of in-depth research, the US pharmaceuticals company Bristol-Myers
Squibb is now launching this agent on the American market as a treatment for cancer.The
epothilones that Prof. Gerhard Höfle and Prof. Hans Reichenbach of the HZI have been
studying for more than 20 years are produced by myxobacteria living in the soil.
Epothilones block the somatic cell components known as microtubules, preventing the cells
from dividing any further and causing them to die off and decompose. The effect of
epothilones on cancerous cells, which are characterised by their tendency to divide
uncontrollably, is particularly dramatic: tumours can shrink or even disappear.
Mayo Clinic Researchers Find
Experimental Therapy Turns on Tumor Suppressor Gene in Cancer Cells
Researchers at Mayo Clinic have found that the experimental drug they are testing to treat
a deadly form of thyroid cancer turns on a powerful tumor suppressor capable of halting
cell growth. Few other cancer drugs have this property, they say. In the Feb. 15 issue of
Cancer Research (available online Jan. 20), they report that RS5444, being tested in a
Phase 1/2 clinical trial to treat anaplastic thyroid cancer, might be useful for treating
other cancers. The agent is also known as CS-7017. From previous research, the
investigators knew that RS5444 binds to a protein known as PPAR-gamma, a transcriptional
factor that increases the expression of many genes. They had found that human anaplastic
thyroid tumor cells treated with RS5444 expressed a protein known as p21, which inhibited
cell replication and tumor growth. But they did not understand how. They have now
discovered that the agent actually forces PPAR-gamma to turn on the RhoB tumor suppressor
gene, which in turn induces p21 expression. "This is very unusual," says the
study's lead investigator, John Copland, Ph.D., a cancer biologist at the Mayo Clinic
campus at Jacksonville. "Drugs typically target genes and proteins that are
over-expressed and turn them off. We found that RS5444 turns on a valuable tumor
suppressor gene. We rarely find a drug that can take a suppressed gene and cause it to be
re-expressed."
A mouse resistant to cancer, even highly-aggressive types, has been created by researchers
at the University of Kentucky. The breakthrough stems from a discovery by UK College of
Medicine professor of radiation medicine Vivek Rangnekar and a team of researchers who
found a tumor-suppressor gene called "Par-4" in the prostate.
Checking more lymph nodes linked to
cancer patient survival
Why do patients with gastric or pancreatic cancer live longer when they are treated at
cancer centers or high-volume hospitals than patients treated at low-volume or community
hospitals? New research from Northwestern University found that cancer patients have more
lymph nodes examined for the spread of their disease if they are treated at hospitals
performing more cancer surgeries or at comprehensive cancer centers. The result is a more
accurate prognosis and treatment decision, which results in improved long-term outcomes.
Has cancer spread? Research
identifies best way to find answers so treatment can begin
New Saint Louis University research has found that the PET-CT scanner can be used as a
stand-alone tool to detect secondary cancers, which occur in 5 to 10 percent of head and
neck cancer patients.
New mammography technology improves
cancer detection
A new radiological diagnostic tool called stereo mammography allows clinicians to detect
more lesions and could significantly reduce the number of women who are recalled for
additional tests following routine screening mammography. The findings from a clinical
trial underway at Emory University were presented today at the annual meeting of the
Radiological Society of North America held in Chicago. 0
Once-suspect Protein Found To
Promote DNA Repair, Prevent Cancer
An abundant chromosomal protein that binds to damaged DNA prevents cancer development by
enhancing DNA repair, researchers at The University of Texas M. D. Anderson Cancer Center
report online in the Proceedings of the National Academies of Science.
Researchers find new molecule to
block ‘Hedgehog’ signaling in cancer, development
Researchers have achieved a feat drug developers had thought difficult, if not impossible,
discovering a compound that blocks the functioning of a key developmental protein by
binding to an “undruggable” target — an advance that may provide a new
avenue to fight skin, pancreatic, prostate, and other cancers. A team led by Stuart
Schreiber, the Morris Loeb Professor of Chemistry in Harvard’s Faculty of Arts and
Sciences and director of the Broad Institute of Harvard and MIT’s Chemical Biology
Program, discovered a small molecule they dubbed “robotnikinin” that binds
directly to a protein called Sonic Hedgehog. The protein was shown in 1978 to control the
early development of fruit flies, whose bodies developed spiny protrusions when the
protein was blocked. It is now known that Sonic Hedgehog plays an important developmental
role in mammals, including humans, regulating limb and brain development in the embryo and
controlling the division both of adult stem cells and several types of cancer cell.
A new cellular pathway linked to
cancer is identified by NYU researchers
In the life of a cell, the response to DNA damage determines whether the cell is fated to
pause and repair itself, commit suicide, or grow uncontrollably, a route leading to
cancer. In a new study, published in the July 25th issue of Cell, scientists at NYU
Langone Medical Center have identified a way that cells respond to DNA damage through a
process that targets proteins for disposal. The finding points to a new pathway for the
development of cancer and suggests a new way of sensitizing cancer cells to treatment.
We've all seen the term "super food" used to describe those nutrition-loaded
edibles that promote health and discourage disease. Powerhouse foods high in antioxidants
and phytochemicals that block the development of cancer cells have been touted as nature's
way to fight off the potentially devastating disease.
Medical physicists at the University of Virginia have created a novel way to kill tumor
cells using nanoparticles and light. The technique, devised by Wensha Yang, an instructor
in radiation oncology at the University of Virginia, and colleagues Ke Sheng, Paul W.
Read, James M. Larner, and Brian P. Helmke, employs quantum dots. Quantum dots are
semiconductor nanostructures, 25 billionths of a meter in diameter, which can confine
electrons in three dimensions and emit light when exposed to ultraviolet radiation.
That grilled chicken breast touted as a healthy alternative to a bucket of fried chicken
may actually contain cancer-causing compounds. But broccoli is still tops when it comes to
keeping cancer at bay.
A new biomarker for early cancer
detection? Research reveals that 'microRNA' may fit the bill
Scientists at Fred Hutchinson Cancer Research Center have discovered that microRNAs --
molecular workhorses that regulate gene expression -- are released by cancer cells and
circulate in the blood, which gives them the potential to become a new class of biomarkers
to detect cancer at its earliest stages.
Study provides clues to preventing
and treating cancer spread
Researchers from the University of North carolina at Chapel Hill demonstrated for the
first time that normal cells, possibly fibrocytes, may travel to distant organs to create
pre-metastic niches for the spread of cancer.
A fruitful collaboration between chemists and biologists has made it possible to identify
the effects of a new class of molecules, polyoxometalates(1), primarily composed of metals
and oxygen. These molecules are very powerful inhibitors of a specific protein kinase,
CK2, an enzyme that is overactive in a number of cancers. The enzyme's instrumental role
in controlling cell proliferation and survival makes it an important target in the search
for new medications. These results have just been published in the journal Chemistry and
Biology by chemists from the Institut de chimie moléculaire (CNRS / UPMC) and biologists
from the Institut de recherche en technologies et sciences pour le vivant (iRTSV, CEA de
Grenoble / CNRS / Inserm).
A new discovery has been made in cancer research. Researchers from the Laboratoire des
collisions atomiques et moléculaires (CNRS/Université Paris 11) and the Laboratoire
Génotoxicologie et cycle cellulaire (CNRS/Institut Curie) were the first to show that it
is possible to improve hadrontherapy's(1) targeting and destruction of tumor cells by
loading the cells with heavy atoms like platinum.
Children under five years old living near nuclear power stations have contracted cancer at
a greatly higher rate than the national average, a study by the German government said
Saturday.
Pentachlorophenol, a fungicide widely used as a wood preservative, was classified in 1999
by the International Agency for Research on Cancer as a possible human carcinogen. We
reviewed currently available data to determine the extent to which recent studies assist
in distinguishing the effect of pentachlorophenol from that of its contaminants (e.g.,
dioxins and other chlorophenols). The updated cohort study focusing on pentachlorophenol
provides increased statistical power and precision, and demonstrates associations between
hematopoietic cancer and pentachlorophenol exposure not observed in earlier evaluations of
this cohort. Contaminant confounding is an unlikely explanation for the risks seen with
pentachlorophenol exposure.
New "Juice Feasting"
Emerging as Phytonutrient-Rich Disease-Fighting Nutritional System
It's rare for something to come along that impresses me so much as a healing modality that
it instantly changes my own life habits. But I've recently been introduced to a
plant-based medicinal modality that's so incredibly effective at preventing and reversing
disease that I believe it is "the" cure for cancer society has been looking for.
And in this article, I'm going to share with you what I know about this system.
New Evidence for the Protective
Effects of Fruits and Veggies
The age-old refrain, "Eat your vegetables!" gets scientific support as
researchers present the latest findings on cancer prevention at the American Association
for Cancer Research's Sixth Annual International Conference on Frontiers in Cancer
Prevention, being held December 5 - 8 in Philadelphia, Pennsylvania. Today, researchers
present new data that demonstrate how diets full of raw vegetables -- particularly
broccoli sprouts -- and black raspberries could prevent or slow the growth of some common
forms of cancer.
Het injecteren van een hoge dosis vitamine C remt de groei van kankertumoren, in sommige
gevallen zelfs met vijftig procent. Dat concluderen Amerikaanse onderzoekers aan de hand
van proeven op muizen.
High-dose injections of vitamin C, also known as ascorbate or ascorbic acid, reduced tumor
weight and growth rate by about 50 percent in mouse models of brain, ovarian, and
pancreatic cancers.
Cancer is not a Disease - It's a
Survival Mechanism
What you are about to read may rock or even dismantle the very foundation of your beliefs
about your body, health and healing. The title, "Cancer Is Not a Disease" may be
unsettling for many, provocative to some, but encouraging for all. This book will serve as
a revelation for those who are sufficiently open-minded to consider the possibility that
cancer and other debilitating illnesses are not actual diseases, but desperate and final
attempts by the body to stay alive for as long as circumstances permit.
Burning carbohydrate-rich foods
could cause some cancers
Dutch scientists have said in a study that burning your food may lead to certain types of
cancer, particularly in women. Scientists also say that more research is needed to make a
definite determination and that there are other factors that could be to blame.
After having seen thousands of cancer patients over a period of three decades, I began to
recognize a certain pattern of thinking, believing and feeling that was common to most of
them. To be more specific, I have yet to meet a cancer patient who does not feel burdened
by some poor self-image, unresolved conflict and worries, or past emotional trauma that
still lingers in his/her subconscious. Cancer, the physical disease, cannot occur unless
there is a strong undercurrent of emotional uneasiness and deep-seated frustration. Cancer
patients typically suffer from lack of self-respect or worthiness, and often have what I
call an "unfinished business" in their life. Cancer can actually be a way of
revealing the source of such inner conflict. Furthermore, cancer can help them come to
terms with such a conflict, and even heal it altogether. The way to take out weeds is to
pull them out along with their roots. This is how we must treat cancer; otherwise, it may
recur eventually. The following statement, which runs like a red thread through the entire
book, is very important in the consideration of cancer: "Cancer does not cause a
person to be sick; it is the sickness of the person that causes the cancer." To treat
cancer successfully requires the patient to become whole again on all levels of his body,
mind and spirit. Once the cancer causes have been properly identified, it will become
apparent what needs to be done to achieve complete recovery.
Yale Scientist Will Target Cancer
Protein to Cell’s “Recycling System”
Tim Corson, a Yale postdoctoral fellow in the Department of Molecular, Cellular &
Developmental Biology, received two top fellowship honors from the Canadian Institutes of
Health Research (CIHR) in Ottawa on November 20 for his proposal of a research project to
target and destroy a protein commonly active in cancer.
Researchers find cancer-inhibiting
compound under the sea
University of Florida researchers have discovered a marine compound off the coast of Key
Largo that inhibits cancer cell growth in laboratory tests. Largazole, named for its
Florida location and structural features, seeks out a family of enzymes called histone
deacetylase. Overactivity of certain HDACs has been associated with several cancers such
as prostate and colon tumors, and inhibiting HDACs may activate tumor-suppressor genes
that have been silenced in these cancers.
High-potency vitamins, melatonin supplements, and other complementary remedies may help to
relieve the debilitating pain and fatigue experienced by most people with advanced
pancreatic cancer, a new study suggests.
Researchers discover how tumor
suppressor inhibits cell growth
New work by researchers at the University of California, San Diego, School of Medicine
describes the mechanism by which p53 regulates cells and protects them against DNA damage
that might lead to cancer. The study shows that two p53 target genes -- called Sestrin1
and Sestrin2 -- provide an important link between p53 and a protein kinase called mTOR, a
central regulator of cell growth.
Microchip-based device can detect
rare tumor cells in bloodstream
A team of investigators from the MGH BioMEMS Resource Center and the MGH Cancer Center has
developed a microchip-based device that can isolate, enumerate and analyze circulating
tumor cells from a blood sample.
Cancer is a degenerative disease caused by a lack of vitamins and poisoning from chemical
substances present in food. One can estimate the number of vitamins andpro-vitamin
substances present in natural plants commonly used as food by humans, as more than 15,000
to 30,000. The introduction into modern agriculture of Genetically Modified Organisms
(GMOs) is an unjustified and dangerous alteration of what Evolution has produced in plants
over hundreds of millions of years: plants on which the subsequent biochemical evolution
of superior complex animal organisms has been based, culminating with the advent of
mammals in the last 65 million years and then with the arrival of Man.
In the pre-cancerous condition, all is prepared. The liver is sufficiently damaged and the
other organs of the intestinal tract are damaged enough and then later the symptoms
appear. Until then we have the pre-cancerous condition and this condition cannot be cured
with hormones and enzymes, etc. We can to a certain degree stimulate the liver with
hormones. We can stimulate the liver with cortisone. We can stimulate the liver with
adrenalin etc., but then we take out the last reserves. We empty the liver instead of
refilling it. What we have to do in cancer -a degenerative, deficiency disease- is to
refill the organs which are empty and poisoned. Therefore it is almost a crime to give
cortisone and the other stimulants which will take away the last reserves and improve the
condition for a short while only.
Plant Constituent with Selective
Effect on Cancer Cells
The substance wogonin triggers the death program apoptosis in tumor cells, while it has
virtually no effect on healthy cells. Scientists of the German Cancer Research Center
(Deutsches Krebsforschungszentrum, DKFZ) have discovered the molecular mechanism
underlying this selectivity. Defects in genes that control growth can turn a cell into a
threat for the whole organism. Defective cells that might get out of control are driven
into suicide by a protective mechanism called apoptosis. However, this life saving
mechanism is no longer working in most tumor cells, since numerous molecules regulating
apoptosis are defective. This is why researchers have been trying for some time to restore
the capability of controlled suicide in tumor cells. However, this is a risky venture,
because it involves the danger of damaging healthy tissue, too, by cell death. Therefore,
scientists have urgently been searching for substances that induce cell death selectively
in tumor cells.
Targeted radiation therapy can
control limited cancer spread
Precisely targeted radiation therapy can eradicate all evidence of disease in selected
patients with cancer that has spread to only a few sites, suggests the first published
report from an ongoing clinical trial. Radiation therapy controlled all signs of cancer in
21 percent of patients who had five or fewer disease sites.
Gene's newly explained effect on
height may change tumor disorder treatment
A mutation that causes a childhood tumor syndrome also impairs growth hormone secretion,
researchers at Washington University School of Medicine in St. Louis have found. The
discovery provides new insights into an old mystery, revealing why patients with
neurofibromatosis type 1 are frequently shorter than their peers.
Monash researchers uncover cancer
survival secrets
A team of Monash University researchers has uncovered the role of a family of enzymes in
the mutation of benign or less aggressive tumours into more aggressive, potentially fatal,
cancers in the human body.
Treating oft ignored non-cancer
health issues after cancer diagnosis prolongs survival
Receiving treatment for non-cancer health issues while being treated by specialists for
cancer improves cancer survival rates according to a study published in the Dec. 20 issue
of the Journal of Clinical Oncology.
Key to Treating Cancer May Be
Finding its Original Cell
Cancer biologists are turning their attention to the normal cells that give rise to
cancers, to learn more about how tumor growth might be stopped at the earliest
opportunity. "Identifying the specific, normal cells that cancers come from can
provide critical insight into how cancers develop," said Robert Wechsler-Reya, an
associate professor of Pharmacology and Cancer Biology at Duke University Medical Center.
"This may help us develop more rational and effective approaches to treatment."
Every cancer comes from a normal cell. The hard part is finding the cell at the root of
each particular subtype of cancer. For the first time, the Duke team has identified two
types of cells in the brain that can give rise to the malignant brain tumor
medulloblastoma. This dangerous cancer, which occurs most commonly in children, is
currently treated with a combination of surgery, chemotherapy and radiation, which have
extremely severe side effects, said Wechsler-Reya, who is a member of the Preston Robert
Tisch Brain Tumor Center at Duke.
Chemists are pulling cancer onto a sucker punch by getting infected cells to drop their
guard – according to research published today. They are using the metal ruthenium as
a catalyst to a cancer-busting reaction which calls up an old cellular enemy –
oxidants – as an ally.Cancer adapts quickly to traditional drugs which attack
infected cells directly. But the latest laboratory tests reveal a second line of defence
using ruthenium as a catalyst to a reaction which stops cells developing the anti-oxidant
chemical glutathione. As the targeted cell is forced to drop its glutathione defences, the
oxidant levels increase, and the cancerous cell dies. University of Warwick Chemistry
Professor Peter Sadler explained: "We know oxidants produce free radicals that damage
cells. Our experiments show ruthenium produces a reaction in the cell which destroys its
anti-oxidant defence glutathione – thus destroying the cancer-infected cell.
"Working with colleagues in Edinburgh University and Oncosense we've proved this
could be an effective line of defence against cancer." Scientists working on the
project now hope to move the research out of the laboratory – the next stage for this
work would be medical trials.
Vitamin D could become a useful weapon in the fight against MS, osteoporosis, mild
depression and one of the most devastating diseases of our time – cancer.
Cell-death receptor links cancer
susceptibility and inflammation
Researchers demonstrated for the first time a link between cell-death-inducing TRAIL's
receptor and cancer susceptibility. Unexpectedly, they also found a connection -- via
TRAIL -- between inflammation and cancer susceptibility.
The theory behind the work of Gaston Naessens is that cancer is caused by a friendly
microorganism (present in all cells) that becomes unfriendly. 714X provides nitrogen to
the cancer cells, thus causing this microorganism (somatids - "little bodies")
to cease excreting their toxic compounds and the immune system is mobilized. I presume
that at that point the immune system kills the cancer cells. "Furthermore, the 714X
therapy unclogs the lymph system, which is responsible for removing toxins from the
body."
714X is a product created to improve health by revitalizing the immune system. It is not
designed to destroy diseased cells nor to act directly on disease related symptoms. 714X
rather acts upon the lymph, a circulation paralleling the blood stream. This product
supports natural defenses (including the immune system) and must be specifically
introduced into the lymphatic system so that its mode of action may be accomplished.
Cell Phone Radiation Triggers
Measurable Brain Cell Changes in Mere Minutes
As little as 10 minutes on a cell phone can trigger changes in brain cells linked to cell
division and cancer, suggests a new study conducted by researchers from the Weizmann
Institute of Science in Israel and published in the Biochemical Journal.
Light powered platinum more
targeted & 80 times more powerful than similar cancer treatments
Researchers from the Universities of Warwick, Edinburgh, Dundee and the Czech
Republic’s Institute of Biophysics have discovered a new light-activated
platinum-based compound that is up to 80 times more powerful than other platinum-based
anti-cancer drugs and which can use "light activation" to kill cancer cells in
much more targeted way than similar treatments.
Cancer is characterized by proliferation of abnormal cells which multiply out of control,
destroying healthy tissue and endangering life. This unchecked "cancerous"
growth spreads throughout the body, interfering with the ability of cells, organs, and
other structures to perform their normal functions.
Super-microscopes and suppressed
cancer treatments
Incredibly, Naessens' research has resulted in the association of degenerative diseases
(rheumatoid arthritis, multiple sclerosis, lupus, cancer and AIDS) with the development of
forms in the sixteen-stage pathological cycle. The ability to associate the disease with
specific stages has enabled Naessens to 'prediagnose' conditions in advance of when they
would clinically appear.This discovery puts Gaston Naessens at odds with the orthodox
medical philosophy today which has embraced Pasteur's germ theory wholeheartedly.
Naessens' work is repeatable. The ability to culture somatids is a bellwether to the
rewriting of microbiology!
Novel anticancer strategy moves
from laboratory to clinic
Researchers have developed a novel anti-tumor compound that represents a distinct
strategy: targeting one of the most important "intercept points" for cancer
cells.
How do you hit a moving target when that target is a tumor? A breakthrough in radiation
treatment is giving doctors a new, more accurate way to attack tumors that uses
four-dimensional imaging to zero-in on cancer.
UCSD research team identifies novel
anticancer drug from the sea
A collaborative team of researchers spearheaded by Dennis Carson M.D., professor of
medicine and director of the Rebecca and John Moores UCSD Cancer Center at the University
of California, San Diego has identified a potent new anticancer drug isolated from a toxic
blue-green algae found in the South Pacific.
New research may help explain why an anti-cancer drug causes potentially fatal brain
inflammation in certain patients. Scientists at Harvard Medical School mimicked the drug's
activity in mice and found that it damaged the cell lining that prevents fluid from
leaking from the spinal cord into the brain. The results will be published online on Feb.
11 in the Journal of Experimental Medicine.
Patient with rare disorder responds
to cancer drug
A rare disorder caused by an excess of two types of immune cells -- the mast cell found in
various tissues and its blood-based twin, the basophil -- has successfully been treated
with a cancer drug, report scientists from NIAID.
Med school discovery could lead to
better cancer diagnosis, drugs
A Florida State University College of Medicine research team led by Yanchang Wang has
discovered an important new layer of regulation in the cell division cycle, which could
lead to a greater understanding of the way cancer begins. Wang, an assistant professor of
biomedical sciences at the College of Medicine, said the findings will lead to an improved
ability to diagnose cancer and could lead to the design of new drugs that kill cancer
cells by inhibiting cell reproduction. His paper on the discovery has been published in
the journal Proceedings of the National Academy of Sciences. "The correct timing of
chromosome segregation during cell division is necessary to ensure normal, healthy
growth," Wang said. "Now we have discovered a previously undetected layer of
regulation in how the chromosomes separate, which helps to ensure the correct timing and
decreases the potential for the formation of cancerous growth." The cell division
cycle is a collection of tightly regulated events that lead to cell duplication. The most
important events are the doubling of the hereditary information encoded within a set of
chromosomes, and the division of that duplicated information into two daughter cells that
are genetically identical to each other and the mother cell. The correct order of
cell-cycle events is essential for successful cell division. Wang's article addresses the
role of a particular protein enzyme, Cdc14, in ensuring that cell division events occur in
exactly the right order. Defects in the regulation of the order of events can lead to cell
death or the alteration of genetic information, which contributes to the formation of
cancerous cells.
Mechanisms of cardiovascular
disease and cancer give clues to new therapies
Cardiovascular conditions leading to heart attacks and strokes are treated quite
separately from common cancers of the prostate, breast or lung, but now turn out to
involve some of the same critical mechanisms at the molecular level. This in turn provides
clues to more effective therapies for both cancer and cardiovascular diseases, but
requires researchers in these distinct fields to come together. The seeds were sown for
closer cooperation between these two groups at a recent workshop organised by the European
Science Foundation (ESF), which also highlighted the striking progress already made in
understanding key common mechanisms underlying both disease categories.
A compound extracted from olives
inhibits cancer cells growth and prevents their appearance
Scientifics of the University of Granada have found that maslinic acid, present in olive
skin's leaf and wax, acts on antitumor cells controlling their alterations in growth
processes. At present, the only production plant of this substance at a semi-industrial
level in the whole world is at the faculty of sciences of the UGR. This research group has
published results related with this release in the specialized journal FEBS Letters.
Scientists solve structure of gene
regulator that plays key role in cancer
Scientists at the Wistar Institute have collaborated on a major advance in understanding a
gene regulator that contributes to some of the deadliest cancers in humans. Their research
paves the way for the development of new cancer therapies. The scientists have elucidated
the 3-D structure of a key segment of p300/CBP, one of the most studied enzymes in the HAT
family. Aberrant p300/CBP activity contributes to pancreatic, colon, and lung cancer and
also can suppress tumors.
Tiny protein provokes healthy
bonding between cells
In human relationships, a certain "spark" often governs whether we prefer one
person to another. Critical first impressions can occur within seconds. Researchers have
found that cell-to-cell "friendships" operate in much the same way and that
dysfunctional bonding is linked to the spread of cancer.
If you're a cancer cell, you want a protein called Bcl-2 on your side because it decides
if you live or die. It's usually a trusted bodyguard, protecting cancer cells from
programmed death and allowing them to grow and form tumors. But sometimes it turns into
their assassin. Scientists knew it happened, but they didn't know how to actually cause
such a betrayal. Now they do and it may lead to the development of new cancer-fighting
drugs.
Researchers are preparing for clinical trials examining whether high doses of vitamin C,
administered intravenously, can slow the spread of non-Hodgkin's lymphoma.
Researchers uncover key trigger for
potent cancer-fighting marine product
An unexpected discovery in marine biomedical laboratories at Scripps Institution of
Oceanography at UC San Diego has led to new, key information about the fundamental
biological processes inside a marine organism that creates a natural product currently
being tested to treat cancer in humans.
The Radiowave Therapy Research Institute was founded in January 2006 for the purpose of
studying radiowave therapy as was practiced by Dr John Holt over a 30 year period. The
Radiowave Therapy Research Institute is a purpose built facility offering state of the art
medical assistance and facilities. The Institute is privately funded.
NIGMS-funded researchers have solved the structure of an enzyme (PIK3CA) that is mutated
in cancers of the colon, brain, stomach, breast, lung, and others.
Many of the cancer drugs currently undergoing clinical trials target IAPs, since if the
levels of IAPs are reduced, tumor cells will be destroyed by the body's own
self-protecting mechanism or by the chemotherapeutic drugs. However, as a research group
from the Goethe University in Frankfurt, working with scientists at the Universities of
Wuerzburg and Philadelphia have recently discovered, IAPs also have another life: they
control cell migration.
This site is to help inform people of the exciting research done on DCA by scientists at
the University of Alberta. In January 2007, a team of scientists at the University of
Alberta published a paper in the scientific journal, Cancer Cell, describing the discovery
that a simple, cheap molecule, DCA, worked to reactivate the apoptosis mechanism of cancer
cells, causing rapid shrinkage of tumors in rats. Mitochondrial reactivation represents an
entirely new approach to treating cancer.
To decipher how cancer develops, Johns Hopkins Kimmel Cancer Center investigators say
researchers must take a closer look at the packaging. Specifically, their findings in the
December 2, 2008, issue of PLoS Biology point to the three dimensional chromatin packaging
around genes formed by tight, rosette-like loops of Polycomb group proteins (PcG). The
chromatin packaging, a complex combination of DNA and proteins that compress DNA to fit
inside cells, provides a repressive hub that keeps genes in a low expression state.
“We think the polycomb proteins combine with abnormal DNA methylation of genes to
deactivate tumor suppressor genes and lock cancer cells in a primitive state,” says
Stephen B. Baylin, M.D., Virginia and D.K. Ludwig Professor of Oncology and senior author.
Prior to this discovery, investigators studying cancer genes, looked at gene silencing as
a linear process across the DNA, as if genes were flat, one dimensional objects. Research
did not take into account the way genes are packaged.
While studying the mechanics of blood clots, researchers at the University of Oklahoma
Health Sciences Center discovered a new enzyme that not only affects the blood, but seems
to play a primary role in how cancer tumors expand and spread throughout the body. The
research appeared in recent issues of the journal Blood and the Journal of Thrombosis and
Haemostasis. A research group at OU led by Patrick McKee first discovered the enzyme
called sFAP in plasma. After studying the biochemical makeup of the protein and
identifying the gene that controlled its function, they began to search gene sequencing
databases worldwide to find what it was. They didn’t find the enzyme listed for
blood, but got a match with a virtually identical protein known to cause cell growth in
tissue, including in cancer. With McKee’s discovery that the protein also exists in
blood, scientists have a new avenue to study the spread of cancer.
Stanford blood scanner detects even
faint indicators of cancer
A team led by Stanford researchers has developed a prototype blood scanner that can find
cancer markers in the bloodstream in early stages of the disease, potentially allowing for
earlier treatment and dramatically improved chances of survival. The system based on
MagArray biodetection chips can find cancer-associated proteins in a blood serum sample in
less than an hour, and with much greater sensitivity than existing commercial devices. In
fact, the device, which uses magnetic nanotechnology to spot the cancer proteins, is tens
to hundreds of times more sensitive, meaning the proteins can be found while there are
relatively few of them in the bloodstream. The researchers reported their results in the
Dec. 1 online edition of the Proceedings of the National Academy of Sciences. "This
is essentially a proof-of-concept study showing that now we have a chip and a reader that
can find multiple biomarkers in a sample at a concentration much lower than the standard
that is commercially available," said Shan Wang, a Stanford professor of materials
science and of electrical engineering.
Rice University chemists have found a way to package some of nature's most powerful
radioactive particles inside carbon nanotubes. Alpha-particle radiation is so powerful
that cancer cells can be destroyed with just one direct hit from an alpha particle on a
cell nucleus. Rice's researchers hope to use their new technology to target tiny tumors
and even lone leukemia cells. Their research is available online from the journal Small.
The popular Papua New Guinean pastime of chewing betelnut, linked to health problems
including mouth cancer, may reduce the risk of diabetes, new research shows.
THE High pH Therapy for cancer was arrived at from an extensive series of physical
experiments. These involved the isotope effect across membranes of many types, normal
plant and animal, embryonic, cancer, and synthetic. It also involved mass spectrographic
analyses of membranes and cells, as well as fluorescence and phosphorescence decay studies
of many types of cells and parts thereof. It is the thesis of this paper that the results
obtained throw a direct light upon the mechanism of carcinogenesis, and also indicate a
therapy.
Electric fields have potential as a
cancer treatment
Low-intensity electric fields can disrupt the division of cancer cells and slow the growth
of brain tumors, suggest laboratory experiments and a small human trial, raising hopes
that electric fields will become a new weapon for stalling the progression of cancer. The
August 2007 issue of Physics Today describes the mechanisms by which the electric fields
do their work.
